Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …

A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons
are an early characteristic of Down syndrome (DS) and Alzheimer's disease (AD). We have …

Background Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and
in neurodegenerative disorders, including in Alzheimer's disease, in Down syndrome, and in …

Abstract β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly
implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked …

The most common genetic cause of intellectual disability is Down syndrome (DS), trisomy
21. It commonly results from three copies of human chromosome 21 (HC21). There are no …

Background Overexpression of the transsulfuration enzyme cystathionine-β-synthase (CBS),
and overproduction of its product, hydrogen sulfide (H 2 S) are recognized as potential …

The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset
Alzheimer's disease (AD). However, the reason for the association between APOE4 and AD …