Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet… - Pharmacological …, 2018 - Elsevier
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

MK Ahmmed, F Ahmmed, H Tian… - … reviews in food …, 2020 - Wiley Online Library
For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

The role of lipids in Parkinson's disease

H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Emerging class of omega-3 fatty acid endocannabinoids & their derivatives

JE Watson, JS Kim, A Das - Prostaglandins & other lipid mediators, 2019 - Elsevier
Cannabinoid receptor activation is involved in homeostatic regulation of the body. These
receptors are activated by cannabinoids, that include the active constituents of Cannabis …

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

C Fourrier, J Remus-Borel, AD Greenhalgh… - Journal of …, 2017 - Springer
Background Neuroinflammatory processes are considered a double-edged sword, having
both protective and detrimental effects in the brain. Microglia, the brain's resident innate …

On the chemical and biological characteristics of multifunctional compounds for the treatment of Parkinson's disease

O García-Beltrán, PJ Urrutia, MT Núñez - Antioxidants, 2023 - mdpi.com
Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative
damage and inflammation are pathognomonic features of Parkinson's disease (PD) and …

Modulating tumor-associated macrophage polarization by synthetic and natural PPARγ ligands as a potential target in breast cancer

G Gionfriddo, P Plastina, G Augimeri, S Catalano… - Cells, 2020 - mdpi.com
Activation of peroxisome proliferator-activated receptor gamma (PPARγ) elicits anti-
proliferative effects on different tumor cells, including those derived from breast cancer …

Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain

J Balakrishnan, S Kannan, A Govindasamy - Nutrition Research, 2021 - Elsevier
Docosahexaenoic acid (DHA) is one of the most important fatty acids that plays a critical role
in maintaining proper brain function and cognitive development. Deficiency of DHA leads to …

Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products

P Plastina, C Benincasa, E Perri, A Fazio, G Augimeri… - Food chemistry, 2019 - Elsevier
Hydroxytyrosyl esters with short, medium and long acyl chains were evaluated for their
ability to reduce nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264. 7 …