Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Evolving interest in meningioma, the most common primary brain tumor, has refined
contemporary management of these tumors. Problematic, however, is the paucity of …

Accounting for over a third of all primary CNS neoplasms, meningiomas are amongst the
most common diagnoses encountered in neurosurgical practice. Like their non-neoplastic …

Although most meningiomas are encapsulated and benign tumors with limited numbers of
genetic aberrations, their intracranial location often leads to serious and potentially lethal …

Background Previous reports have shown that overall incidence of malignant brain and
other central nervous system (CNS) tumors varied significantly by country. The aim of this …

Background Phase 2 cooperative group meningioma trial assessing the safety and efficacy
of risk-adaptive management strategies. This is the initial analysis of the high-risk cohort …

Abstract Epidemiologists in the Brain Tumor Epidemiology Consortium (BTEC) have
prioritized areas for further research. Although many risk factors have been examined over …

Gliomas account for almost 80% of primary malignant brain tumors, and they result in more
years of life lost than do any other tumors. Glioblastoma, the most common type of glioma, is …

OBJECTIVE This is the first clinical outcomes report of NRG Oncology RTOG 0539, detailing
the primary endpoint, 3-year progression-free survival (PFS), compared with a predefined …

OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma;
however, no association has been shown between meningioma tumor size and tumor …