Glypican‐3: a promising biomarker for hepatocellular carcinoma diagnosis and treatment
Liver cancer is the second leading cause of cancer‐related deaths, and hepatocellular
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers
BD White, AJ Chien, DW Dawson - Gastroenterology, 2012 - Elsevier
Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …
[PDF][PDF] Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis
R Liu, X Li, W Zhu, Y Wang, D Zhao, X Wang… - …, 2019 - Wiley Online Library
Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …
Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Aβ42: Aβ40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the …
WJ Meilandt, H Ngu, A Gogineni… - Journal of …, 2020 - Soc Neuroscience
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of
Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus …
Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus …
[HTML][HTML] Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances
R Dhanasekaran, S Bandoh, LR Roberts - F1000Research, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an
increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced …
increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced …
Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study
Background Hepatocellular carcinoma is a frequent consequence of alcohol-related liver
disease, with variable incidence among heavy drinkers. We did a genome-wide association …
disease, with variable incidence among heavy drinkers. We did a genome-wide association …
Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 …
NS Srivastava, RAK Srivastava - Phytomedicine, 2019 - Elsevier
Background Traditional therapy using natural products, especially flavonoids and alkaloids
have been in practice for a long time. Among flavonoids, curcumin, quercetin, berberine, and …
have been in practice for a long time. Among flavonoids, curcumin, quercetin, berberine, and …
Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression
A Nagarajan, P Malvi, N Wajapeyee - Frontiers in endocrinology, 2018 - frontiersin.org
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily
modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains …
modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains …
[PDF][PDF] MicroRNA‐223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases ranging from
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …
The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumor microenvironment and opportunities for novel cancer …
E Hammond, A Khurana, V Shridhar… - Frontiers in oncology, 2014 - frontiersin.org
Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue
architecture at the cell surface and within the extracellular matrix. The modification of HSPGs …
architecture at the cell surface and within the extracellular matrix. The modification of HSPGs …