G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

E Ruggiero, SN Richter - Nucleic acids research, 2018 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - Elsevier
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

Structure of an RNA G-quadruplex from the West Nile virus genome

JR Terrell, TT Le, A Paul, MA Brinton… - Nature …, 2024 - nature.com
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …

G-quadruplex targeting in the fight against viruses: An update

E Ruggiero, I Zanin, M Terreri, SN Richter - International journal of …, 2021 - mdpi.com
G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

G-quadruplex-binding proteins: promising targets for drug design

H Shu, R Zhang, K Xiao, J Yang, X Sun - Biomolecules, 2022 - mdpi.com
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

D Ji, M Juhas, CM Tsang, CK Kwok, Y Li… - Briefings in …, 2021 - academic.oup.com
The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global
health emergency. G-quadruplex structures in genomes have long been considered …

The evolution of Zika virus from Asia to the Americas

ZY Liu, WF Shi, CF Qin - Nature Reviews Microbiology, 2019 - nature.com
Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …

[HTML][HTML] Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control

P Schult, BM Kümmerer, M Hafner, K Paeschke - Cell Host & Microbe, 2024 - cell.com
Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in
DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of …

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

E Ruggiero, SN Richter - Annual reports in medicinal chemistry, 2020 - Elsevier
Viruses are the most abundant organisms on our planet, affecting all living beings: some of
them are responsible for massive epidemics that concern health, national economies and …