Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase
transitions, but the functional impact of RNA gelation is completely unknown. Here, we …

The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal
counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

Translation elongation is a key step of protein synthesis, during which the nascent
polypeptide chain extends by one amino acid residue during one elongation cycle. More …

Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba
histolytica. Our previous study found that MLIF protects against ischemic stroke in rats and …

Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …

The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target
for protein misfolding neurodegenerative diseases, in which its overactivation results in …

Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …