The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

Production of small ribosomal subunits initially requires the formation of a 90 S precursor
followed by an enigmatic process of restructuring into the primordial pre-40 S subunit. We …

Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in
a highly coordinated manner. More than 200 factors ensure correct modification, processing …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …

The formation of eukaryotic ribosomal subunits extends from the nucleolus to the cytoplasm
and entails hundreds of assembly factors. Despite differences in the pathways of ribosome …

The 90 S preribosome is a large, early assembly intermediate of small ribosomal subunits
that undergoes structural changes to give a pre-40 S ribosome. Here, we gained insight into …

Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural
scaffold and the catalytic center of protein synthesis in every living organism. In eukaryotes …