Huperzine alkaloids: forty years of total syntheses

B Cheng, L Song, F Chen - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2023 Huperzine alkaloids are a group of natural products belonging to the
Lycopodium alkaloids family. The representative member huperzine A has a unique …

Merging continuous flow technology, photochemistry and biocatalysis to streamline steroid synthesis

E Tomarelli, B Cerra, FG Mutti… - Advanced Synthesis & …, 2023 - Wiley Online Library
Since their structural elucidation in 1935, the introduction and substitution of functional
groups and the modification of the steroidal scaffolds have been a fertile ground of research …

Continuous Flow Chemistry with Solids: A Review

HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …

Divergent Chemo‐ and Biocatalytic Route to 16β‐Methylcorticoids: Asymmetric Synthesis of Betamethasone Dipropionate, Clobetasol Propionate, and …

J Wei, Y Zhang, M Liu, Y Ning, Y Cao… - Angewandte Chemie …, 2024 - Wiley Online Library
Abstract 16β‐Methylcorticoids are among the most important glucocorticoid steroids for the
treatment of various dermatological disorders, respiratory infections, and other allergic …

Continuous flow synthesis of 1, 4-disubstituted 1, 2, 3-triazoles via consecutive β-azidation of α, β-unsaturated carbonyl compounds and CuAAC reactions

G Brufani, F Valentini, G Rossini, L Carpisassi… - Green …, 2023 - pubs.rsc.org
We herein report a multi-step flow protocol for the synthesis of 1, 4-disubstituted 1, 2, 3-
triazoles starting from α, β-unsaturated carbonyls. Best results, both in terms of chemical …

Mechanism study and formula development by numerical simulation and visualization experiment in a microfluidic system for enhanced oil recovery

H Zhang, H Ye, H Liu, W Zhang, S Wang, S Zhao… - Chemical Engineering …, 2024 - Elsevier
In this study, microfluidic system was adopted to investigate the effects of hydrodynamic
factors on chemical flooding. The combination of visualization experiments and …

[HTML][HTML] N-Doped graphene fiber anchored Pd nanoparticles as a fixed-bed catalyst for continuous-flow reduction of N-containing unsaturated compounds

S Du, Z Bi, J Xi - Green Synthesis and Catalysis, 2024 - Elsevier
Catalytic fixed-bed is an efficient and facile system for scalable organic synthesis due to its
continuous and fast flow operation process. As a key unit in the fixed-bed system …

Application of Spectroscopy Techniques for Monitoring (Bio) Catalytic Processes in Continuously Operated Microreactor Systems

T Jurina, TS Cvetnić, A Šalić, M Benković, D Valinger… - Catalysts, 2023 - mdpi.com
In the last twenty years, the application of microreactors in chemical and biochemical
industrial processes has increased significantly. The use of microreactor systems ensures …

Continuous flow (Sulfated) Zirconia Catalysed Cascade Conversion of Levulinic Acid to γ‐Valerolactone

A Merenda, SA Orr, Y Liu, B Hernández Garcia… - …, 2023 - Wiley Online Library
Abstract γ‐Valerolactone (GVL) is a renewable and versatile platform chemical derived from
sustainable carbon feedstocks. The cascade conversion of levulinic acid into GVL requires …

Photo-induced 1, 2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions: Rapid, scalable and sustainable approach to 2-arylpropionic acids

Q Li, M Liu, M Jiang, L Wan, Y Ning, FE Chen - Chinese Chemical Letters, 2024 - Elsevier
We report the photo-mediated 1, 2-aryl migration of 2‑chloro-1-arylpropanones to 2-
arylpropionic acids using HCOONa as an acid scavenger. This pragmatically focused study …