Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

Most microbial communities consist of a genetically diverse assembly of different organisms,
and the level of genetic diversity plays an important part in community properties and …

In multicellular organisms, biological function emerges when heterogeneous cell types form
complex organs. Nevertheless, dissection of tissues into mixtures of cellular subpopulations …

Human cancers are complex ecosystems composed of cells with distinct phenotypes,
genotypes, and epigenetic states, but current models do not adequately reflect tumor …

From the homeostasis of human health to the cycling of Earth's elements, microbial activities
underlie environmental, medical and industrial processes. These activities occur in chemical …

Biological systems use a variety of mechanisms to maintain their functions in the face of
environmental and genetic perturbations. Increasing evidence suggests that, among their …

Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …

The importance of whole-genome duplication (WGD) for evolution is controversial. Whereas
some view WGD mainly as detrimental and an evolutionary dead end, there is growing …

The ability to adapt to stimuli is a defining feature of many biological systems and critical to
maintaining homeostasis. While it is well appreciated that negative feedback can be used to …