The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …

Substantial evidence has supported the role of endothelial cell (EC) activation and
dysfunction in the development of hypertension, chronic kidney disease (CKD), and lupus …

We have shown that excessive endothelial cell stretch causes release of growth arrest-
specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and …

Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …

Sepsis is a major health threat and often results in heart failure. Growth arrest-specific gene
6 (GAS6), a 75-kDa vitamin K-dependent protein, participates in immune regulation and …

BACKGROUND: Neutrophil extracellular traps (NETs) are composed of DNA, enzymes, and
citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs …

BACKGROUND: Hypertension is characterized by CD8+ (cluster differentiation 8) T cell
activation and infiltration into peripheral tissues. CD8+ T cell activation requires proteasomal …

Background Macrophage infiltration and polarization are crucial for the pathogenesis of
intracranial aneurysm (IA) rupture. Axl, a receptor tyrosine kinase, is involved in …

Posttranslational modifications can enhance immunogenicity of self-proteins. In several
conditions, including hypertension, systemic lupus erythematosus, and heart failure …

Major surgery induces systemic inflammation leading to pro-inflammatory activation of
endothelial cells. Endothelial inflammation is one of the drivers of postoperative organ …