AIM The “2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial
Fibrillation” provides recommendations to guide clinicians in the treatment of patients with …

The prothrombotic state in atrial fibrillation (AF) occurs as a result of multifaceted
interactions, known as Virchow's triad of hypercoagulability, structural abnormalities, and …

Cells respond to stress by activating a variety of defense signaling pathways, including cell
survival and cell death pathways. Although cell survival signaling helps the cell to recover …

There has been sustained focus on the secondary prevention of coronary heart disease and
heart failure; yet, apart from stroke prevention, the evidence base for the secondary …

Background: IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed
in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an …

Aims The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth
factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to …

BACKGROUND: Hypertension is characterized by CD8+ (cluster differentiation 8) T cell
activation and infiltration into peripheral tissues. CD8+ T cell activation requires proteasomal …

Lipid peroxidation results in generation of a variety of lipid hydroperoxides and other highly
reactive species that covalently modify proteins, nucleic acids, and other lipids, thus …

Posttranslational modifications can enhance immunogenicity of self-proteins. In several
conditions, including hypertension, systemic lupus erythematosus, and heart failure …

Oxidative injury due to elevated levels of reactive oxygen species is implicated in
cardiovascular diseases, Alzheimer's disease, lung and liver diseases, and many cancers …