Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

L Xia, R Zhao, Q Wan, Y Wu, Y Zhou, Y Wang… - Cancer …, 2020 - Wiley Online Library
Objective The purpose of this umbrella review was to assess the associations between
sarcopenia and adverse health‐related outcomes. Design An umbrella review of meta …

Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease

E Makri, A Goulas, SA Polyzos - Archives of medical research, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an
estimated rising prevalence, in concert with the epidemics of obesity and type 2 diabetes …

NAFLD, insulin resistance, and diabetes mellitus type 2

M Marušić, M Paić, M Knobloch… - Canadian Journal of …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …

The role of tumor necrosis factor-alpha in the pathogenesis and treatment of nonalcoholic fatty liver disease

ID Vachliotis, SA Polyzos - Current obesity reports, 2023 - Springer
Abstract Purpose of Review To summarize experimental and clinical evidence on the
association between tumor necrosis factor-α (TNF-α) and nonalcoholic fatty liver disease …

Nonalcoholic fatty liver disease and hepatocellular carcinoma: Insights in epidemiology, pathogenesis, imaging, prevention and therapy

SA Polyzos, L Chrysavgis, ID Vachliotis… - Seminars in cancer …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is estimated to be the third leading cause of cancer-related
mortality and is characterized by low survival rates. Nonalcoholic fatty liver disease (NAFLD) …

Irisin in metabolic diseases

SA Polyzos, AD Anastasilakis, ZA Efstathiadou… - Endocrine, 2018 - Springer
Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Adipokines in nonalcoholic fatty liver disease

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2016 - Elsevier
Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

AP Rolo, JS Teodoro, CM Palmeira - Free radical biology and medicine, 2012 - Elsevier
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

Sarcopenic obesity

SA Polyzos, AN Margioris - Hormones, 2018 - Springer
Sarcopenic obesity, a chronic condition, is today a major public health problem with
increasing prevalence worldwide, which is due to progressively aging populations, the …