Four-membered monocyclic aza-heterocycles, 1 despite their indisputable importance as
bioactive compounds and pharmaceutical tools, have received by the chemical community …

Cycloaddition reactions between ketenes, bearing amino‐, oxy‐, or halo‐groups, and imines
are recognized as being amongst the most important and direct routes to β‐lactams. Alkyl …

Evaluating the aromaticity of a molecular system and the influence of this concept on its
properties is a crucial step in the development of novel aromatic systems. Modern …

The relative (cis, trans) stereoselectivity of the β-lactam formation is one of the critical issues
in the Staudinger reaction. Although many attempts have been made to explain and to …

1. Introduction b-Lactam or azetidin-2-one is an important structural motif of the penicillin,
cephalosporin, carbapenem, and carbecephem classes of antibiotics. 1 Naturally occurring …

We present herein stereoselective synthesis of novel β-lactams using polyaromatic imines
following the Staudinger reaction. Consistent mechanisms for these results have been …

The carbonylation of carbenes through catalytic cycles is highly desirable due to the
importance of ketene-mediated reactions in organic synthesis. In this investigation, a highly …

In the last two decades, the better understanding of the mechanistic aspects of the β-lactams'
biological activity and their inhibition, and the chemical exploitation of β-lactams as synthetic …

Although Staudinger reported the reaction between ketenes and imines 100 years ago
(1907), this process is still the most general and useful method for the synthesis of β-lactams …

The computational study of pericyclic reactions, an important general class of organic
reactions, now provides information about the transition structures of these processes with …