[HTML][HTML] Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators

D Mondal, D Narwani, S Notta, D Ghaffar… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
Androgen deprivation therapy (ADT) is the mainstay regimen in patients with androgen-
dependent prostate cancer (PCa). However, the selection of androgen-independent cancer …

Dysfunctional Lipid Metabolism—The Basis for How Genetic Abnormalities Express the Phenotype of Aggressive Prostate Cancer

M Alberto, A Yim, N Lawrentschuk, D Bolton - Cancers, 2023 - mdpi.com
Simple Summary Advanced prostate cancer has a higher mortality rate at diagnosis
compared to localised prostate cancer. As such, it is critical to understand the mechanisms …

[HTML][HTML] Potential new approaches for prostate cancer management in resource-limited countries in Africa

MC Bosland, OB Shittu, EE Ikpi… - Annals of Global Health, 2023 - ncbi.nlm.nih.gov
Prostate cancer is a major male malignancy in many sub-Saharan countries in Africa.
Because of resource limitations, screening, early detection, diagnosis, and curative …

Development and evaluation of a PSMA-targeted nanosystem co-packaging docetaxel and androgen receptor siRNA for castration-resistant prostate cancer treatment

Y Zhang, H Duan, H Zhao, L Qi, Y Liu, Z Zhang, C Liu… - Pharmaceutics, 2022 - mdpi.com
Primary prostate cancer (PC) progresses to castration-resistant PC (CRPC) during androgen
deprivation therapy (ADR) in early stages of prostate cancer. Thus, rather than blocking the …

Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer

N Chen, Z Wang, M Chen, Q Ma, Y He… - Cancer Biology & …, 2024 - pmc.ncbi.nlm.nih.gov
Objective: Real-word data on long-acting luteinizing hormone-releasing hormone (LHRH)
agonists in Chinese patients with prostate cancer are limited. This study aimed to determine …

Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells

CE Fonseca-Alves, AF Leis-Filho, ZA Lacerda… - Plos one, 2024 - journals.plos.org
The aberrant activation of HER2 has a pivotal role in bone metastasis implantation and
progression in several tumor types, including prostate cancer (PC). Trastuzumab and other …

Relugolix in the management of prostate cancer

KK Sahu, N Tripathi, N Agarwal… - Expert Review of …, 2022 - Taylor & Francis
Introduction Relugolix is the first oral gonadotrophin-releasing hormone (GnRH) receptor
antagonist. Based on the phase III HERO trial results, relugolix received Food and Drug …

Trend in incidence and clinicopathological characteristics of prostate cancer in Northern Tanzania: analysis from a population based cancer registry data 2015–2021

BN Ngowi, A Mremi, OJ Mbwambo, F Seventh… - BMC cancer, 2024 - Springer
Background Globally, prostate cancer is a common disease among men. However, limited
epidemiological data exists regarding prostate cancer in Tanzania. Consequently, there is …

First, a seat; then, an upgrade

A Sathyanarayanan - Journal of Human Hypertension, 2024 - nature.com
Abstract The Sir Stanley Peart Essay Competition is an annual event run by the British and
Irish Hypertension Society to encourage Early Career Researchers to continue the ethos of …

Expert survey on management of prostate cancer in India: real-world insights into practice patterns

G Bakshi, H Tongaonkar, S Addla, S Menon… - Indian Journal of …, 2022 - journals.lww.com
To gain insights on the diverse practice patterns and treatment pathways for prostate cancer
(PC) in India, the Urological Cancer Foundation convened the first Indian survey to discuss …