Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies
Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
Pyrazolines: a biological review
Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively
researched upon. The ring is quite stable and has inspired chemists to carry out various …
researched upon. The ring is quite stable and has inspired chemists to carry out various …
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …
[HTML][HTML] Synthetic and biological studies of pyrazolines and related heterocyclic compounds
M Yusuf, P Jain - Arabian Journal of Chemistry, 2014 - Elsevier
This review provides a comprehensive survey relating to the synthesis and biological
applications of pyrazolines and related heterocycles in the last five years (2007–2011) …
applications of pyrazolines and related heterocycles in the last five years (2007–2011) …
The state of the art of pyrazole derivatives as monoamine oxidase inhibitors and antidepressant/anticonvulsant agents
D Secci, A Bolasco, P Chimenti… - Current medicinal …, 2011 - ingentaconnect.com
Monoamine oxidase plays a significant role in the control of intracellular concentration of
monoaminergic neurotransmitters or neuromodulators and dietary amines. The rapid …
monoaminergic neurotransmitters or neuromodulators and dietary amines. The rapid …