Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …

Despite the development of new antiepileptic drugs (AEDs),~ 20%–30% of people with
epilepsy remain refractory to treatment and are said to have drug-resistant epilepsy (DRE) …

Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …

Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …

The use of opioid analgesics has a long history in clinical settings, although the
comprehensive action of opioid receptors is still less understood. Nonetheless, recent …

Drug‐resistant epilepsy with uncontrolled severe seizures despite state‐of‐the‐art medical
treatment continues to be a major clinical problem for up to one in three patients with …

Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy,
seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a …

During the past several years, there has been increasing interest in the role of the blood–
brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to …

Development of tolerance (ie, the reduction in response to a drug after repeated
administration) is an adaptive response of the body to prolonged exposure to the drug, and …