Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

To escape replicative senescence, cancer cells have to overcome telomere attrition during
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …

Telomeres shorten during each cellular division, with cumulative attrition resulting in
telomeric damage and replicative senescence. Bypass of replicative senescence …

The cyclic GMP‐AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway
mediates anti‐microbial innate immunity by inducing the production of type I interferons …

Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …

Telomere maintenance by telomerase activation or alternative lengthening of telomeres
(ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in …