The epidermis is a dynamic, continually renewing structure that provides the organism with a
life-sustaining interface with the environment. The major cell type of the epidermis, the …

The capacity to induce neoplasia in human tissue in the laboratory has recently provided a
new platform for cancer research. Malignant conversion can be achieved in vivo by …

Gene knockout technology has provided a powerful tool for functional analyses of genes
expressed preferentially in a particular tissue. Given marked similarities between human …

Cisplatin-based chemotherapy remains the primary treatment for unresectable and
metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop …

Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may
promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D …

The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its
aberrant expression is frequently observed in human cancer. However, the consequences of …

The treatment of massive full-thickness burns with engineered skin substitutes has shown
promise in clinical trials. The majority of skin substitutes are comprised of fibroblasts and/or …

The calcium-binding proteins S100A8 and S100A9 can dimerize to form calprotectin, the
release of which during tissue damage has been implicated in inflammation and metastasis …

A defective epidermal permeability barrier (EPB) in premature birth remains a leading cause
of neonatal death as a result of its associated complications, which include poor temperature …

Summary lntegrin expression is normally confined to the basal layer of the epidermis, but
when epidermal homeostasis is perturbed, the receptors are also expressed by suprabasal …