The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

RNA-based therapeutics: an overview and prospectus

Y Zhu, L Zhu, X Wang, H Jin - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …

Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

miRNA: a promising therapeutic target in cancer

A Menon, N Abd-Aziz, K Khalid, CL Poh… - International journal of …, 2022 - mdpi.com
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy

MJ Ramaiah, AD Tangutur, RR Manyam - Life sciences, 2021 - Elsevier
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Circulating cell-free nucleic acids: main characteristics and clinical application

M Szilágyi, O Pös, É Márton, G Buglyó… - International journal of …, 2020 - mdpi.com
Liquid biopsy recently became a very promising diagnostic method that has several
advantages over conventional invasive methods. Liquid biopsy may serve as a source of …

Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression

ER Asl, M Amini, S Najafi, B Mansoori, A Mokhtarzadeh… - Life sciences, 2021 - Elsevier
Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved
signaling pathway, is reported to be involved in various biological events, including …

Non-coding RNAs regulation of macrophage polarization in cancer

S Mohapatra, C Pioppini, B Ozpolat, GA Calin - Molecular cancer, 2021 - Springer
Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions
were extensively studied for the last two decades and the plethora of discoveries have …

The role of microRNAs in neurodegenerative diseases: a review

S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

Therapeutic potential of luteolin on cancer

M Çetinkaya, Y Baran - Vaccines, 2023 - mdpi.com
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …