Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …

Maternal inflammation and its ramifications on fetal neurodevelopment

HK Kwon, GB Choi, JR Huh - Trends in immunology, 2022 - cell.com
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …

Prevalence of Autism Spectrum Disorder in a large Italian catchment area: A school-based population study within the ASDEU project

A Narzisi, M Posada, F Barbieri, N Chericoni… - Epidemiology and …, 2020 - cambridge.org
AimsThis study aims to estimate Autism Spectrum Disorders (ASD) prevalence in school-
aged children in the province of Pisa (Italy) using the strategy of the ASD in the European …

Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative review

C Tye, AK Runicles, AJO Whitehouse… - Frontiers in …, 2019 - frontiersin.org
Co-occurring medical disorders and associated physiological abnormalities in individuals
with autism spectrum disorder (ASD) may provide insight into causal pathways or underlying …

Microbiota influence the development of the brain and behaviors in C57BL/6J mice

J Lu, S Synowiec, L Lu, Y Yu, T Bretherick, S Takada… - PloS one, 2018 - journals.plos.org
We investigated the contributions of commensal bacteria to brain structural maturation by
magnetic resonance imaging and behavioral tests in four and 12 weeks old C57BL/6J …

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in …

MB Hall, DE Willis, EL Rodriguez… - Frontiers in …, 2023 - frontiersin.org
Epidemiological evidence suggests that one's risk of being diagnosed with a
neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases …

Prenatal immune and endocrine modulators of offspring's brain development and cognitive functions later in life

S Schepanski, C Buss, IL Hanganu-Opatz… - Frontiers in …, 2018 - frontiersin.org
Milestones of brain development in mammals are completed before birth, which provide the
prerequisite for cognitive and intellectual performances of the offspring. Prenatal challenges …

Autism spectrum disorder from the womb to adulthood: suggestions for a paradigm shift

C Panisi, FR Guerini, PM Abruzzo, F Balzola… - Journal of personalized …, 2021 - mdpi.com
The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a
challenge for the worldwide healthcare system. With the plethora of information from …

Uncovering the link between air pollution and neurodevelopmental alterations during pregnancy and early life exposure: A systematic review

D Ruiz-Sobremazas, R Rodulfo-Cárdenas… - Neuroscience & …, 2023 - Elsevier
Air pollution plays, nowadays, a huge role in human's health and in the personal economy.
Moreover, there has been a rise in the prevalence of neurodevelopmental disorders like the …