Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Model based care in the ICU: A review of potential combined cardio-pulmonary models

J Cushway, L Murphy, JG Chase, G Shaw, T Desaive… - Plos one, 2024 - journals.plos.org
Positive end-expiratory pressure results in a sustained positive intrathoracic pressure, which
exerts pressure on intrathoracic vessels, resulting in cardiopulmonary interactions. This …

Digital twins in critical care: what, when, how, where, why?

JG Chase, C Zhou, JL Knopp, GM Shaw, K Näswall… - IFAC-PapersOnLine, 2021 - Elsevier
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …

Assessment of dynamic changes in stressed volume and venous return during hyperdynamic septic shock

A Chalkias, E Laou, N Papagiannakis… - Journal of Personalized …, 2022 - mdpi.com
The present work investigated the dynamic changes in stressed volume (Vs) and other
determinants of venous return using a porcine model of hyperdynamic septic shock …

Continuous glucose monitoring to measure metabolic impact and recovery in sub-elite endurance athletes

DG Kulawiec, T Zhou, JL Knopp, JG Chase - Biomedical Signal Processing …, 2021 - Elsevier
Background and motivation Athletes experience substantial physiological impacts after
exhaustive events, including post-exercise hyperglycemia. Objective measurement of …

Physiological trend analysis of a novel cardio-pulmonary model during a preload reduction manoeuvre

J Cushway, L Murphy, JG Chase, GM Shaw… - Computer Methods and …, 2022 - Elsevier
Background and objective: Mechanical ventilation causes adverse effects on the
cardiovascular system. However, the exact nature of the effects on haemodynamic …

Modelling patient specific cardiopulmonary interactions

J Cushway, L Murphy, JG Chase, GM Shaw… - Computers in Biology …, 2022 - Elsevier
Mechanical ventilation is well known for having detrimental effects on the cardiovascular
system, particularly when using high positive end-expiratory pressure. High positive end …

Single measurement estimation of central blood pressure using an arterial transfer function

L Murphy, JG Chase - Computer Methods and Programs in Biomedicine, 2023 - Elsevier
Background: Central blood pressure (BP) better reflects the loading conditions on the major
organs and is more closely correlated with future cardiovascular events. The increased …

[PDF][PDF] Development of non-invasive, optical methods for central cardiovascular and blood chemistry monitoring.

JDC Campbell - 2022 - ir.canterbury.ac.nz
Cardiovascular disease and sepsis are leading causes of mortality, morbidity and high cost
in hospitals around the world. Failure of the circulatory system during cardiogenic shock and …

Cardiovascular Model Identification Using Neural ODE

B Szabó, Á Antal, Á Szlávecz, B Paláncz, K Kovács… - IFAC-PapersOnLine, 2024 - Elsevier
Acute circulatory failure (ACF) is a clinical syndrome when the heart and circulatory
circulation cannot provide adequate blood supply to meet metabolic needs of the organs …