The assembly, regulation and function of the mitochondrial respiratory chain

I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Molecular mechanisms of iron and heme metabolism

S Dutt, I Hamza, TB Bartnikas - Annual review of nutrition, 2022 - annualreviews.org
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders

SW Ryter - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2

V Schulz, S Basu, SA Freibert, H Webert, L Boss… - Nature chemical …, 2023 - nature.com
Ferredoxins comprise a large family of iron–sulfur (Fe–S) proteins that shuttle electrons in
diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] …

Metabolic engineering and synthetic biology strategies for producing high-value natural pigments in Microalgae

K Cao, Y Cui, F Sun, H Zhang, J Fan, B Ge, Y Cao… - Biotechnology …, 2023 - Elsevier
Microalgae are microorganisms capable of producing bioactive compounds using
photosynthesis. Microalgae contain a variety of high value-added natural pigments such as …

Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

An intracellular self‐assembly‐driven uninterrupted ROS generator augments 5‐aminolevulinic‐acid‐based tumor therapy

J Shi, W Nie, X Zhao, X Yang, H Cheng… - Advanced …, 2022 - Wiley Online Library
Free radical therapy based on 5‐aminolevulinic acid (ALA, a precursor of the
photosensitizer protoporphyrin IX (PpIX)) has been approved by the US Food and Drug …

Biosynthesis of High‐Active Hemoproteins by the Efficient Heme‐Supply Pichia Pastoris Chassis

F Yu, X Zhao, J Zhou, W Lu, J Li, J Chen… - Advanced …, 2023 - Wiley Online Library
Microbial synthesis of valuable hemoproteins has become a popular research topic, and
Pichia pastoris is a versatile platform for the industrial production of recombinant proteins …

Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management

ID Cooper, CAP Crofts, JJ DiNicolantonio… - Open …, 2020 - openheart.bmj.com
Risk factors for COVID-19 patients with poorer outcomes include pre-existing conditions:
obesity, type 2 diabetes mellitus, cardiovascular disease (CVD), heart failure, hypertension …

Obesity-dependent adipokine chemerin suppresses fatty acid oxidation to confer ferroptosis resistance

SK Tan, I Mahmud, F Fontanesi, M Puchowicz… - Cancer discovery, 2021 - AACR
Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids
and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and …