Integrin adhesion complexes (IACs) have evolved over millions of years to integrate
metazoan cells physically with their microenvironment. It is presumed that the simultaneous …

While cancer cell proliferation depends on access to extracellular nutrients, inadequate
tumour perfusion means that glucose, amino acids and lipids are often in short supply. To …

Abstract Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has
no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …

Integrins are important regulators of cell survival, proliferation, adhesion and migration.
Once activated, integrins establish a regulated link between the extracellular matrix and the …

Glycogen synthase kinase 3β (GSK3β) phosphorylates and thereby regulates a wide range
of protein substrates involved in diverse cellular functions. Some GSK3β substrates, such as …

Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to
maintain cellular homeostasis; however, mitochondria are still required for migration and …

Triple naegative breast cancer has an increased rate of distant metastasis and consequently
poor prognosis. To metastasize, breast cancer cells must detach from the main tumour mass …

Drug delivery to tumors is limited by several factors, including drug permeability of the target
cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising …

Clathrin-mediated endocytosis is a major regulator of cell-surface protein internalization.
Clathrin and other proteins assemble into small invaginating structures at the plasma …