An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder

BS Da Silva, EH Grevet, LCF Silva, JKN Ramos… - Discover Mental …, 2023 - Springer
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition
characterized by developmentally inappropriate symptoms of inattention and/or …

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - Nature Genetics, 2024 - nature.com
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

[HTML][HTML] Rates of trauma exposure and posttraumatic stress in a pediatric digital mental health intervention: Retrospective analysis of associations with anxiety and …

D Lawrence-Sidebottom, LG Huffman… - JMIR Pediatrics and …, 2024 - pediatrics.jmir.org
Background: More than 2 out of 3 children and adolescents in the United States experience
trauma by the age of 16 years. Exposure to trauma in early life is linked to a range of …

Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian …

B Cabrera-Mendoza, N Aydin, GR Fries… - …, 2024 - nature.com
Bipolar disorder (BD) and schizophrenia (SZ) are associated with higher odds of suicide
attempt (SA). In this study, we aimed to explore the effect of BD and SZ genetic liabilities on …

[HTML][HTML] Attention-deficit/hyperactivity disorder and major depressive disorder: Evidence from multiple genetically informed designs

M Garcia-Argibay, I Brikell, A Thapar, P Lichtenstein… - Biological …, 2024 - Elsevier
Background Attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder
(MDD) are two highly prevalent disorders that frequently co-occur. Prior evidence from …

Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - medRxiv, 2023 - medrxiv.org
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

A bidirectional Mendelian randomization study about the role of morning plasma cortisol in attention deficit hyperactivity disorder

H Jue, L Fang-Fang, C Dan-Fei, C Nuo… - Frontiers in …, 2023 - frontiersin.org
Context Cortisol, a hormone regulated by the hypothalamic-pituitary-adrenal (HPA) axis, has
been linked to attention deficit hyperactivity disorder (ADHD). The nature of the relationship …

Cost-effectiveness and budget impact analysis of lisdexamfetamine versus methylphenidate for patients under 18 with attention-deficit/hyperactivity disorder in Iran

A Tajik, S Nikfar, S Elyasi, O Rajabi… - Child and Adolescent …, 2023 - Springer
Abstract Background Lisdexamfetamine (LDX) and Methylphenidate (MPH) are stimulant
agents that have been shown to provide significant benefits in the management of attention …

Renin-independent aldosteronism and chronic kidney disease in diabetes: observational and Mendelian randomization analyses

J Hu, X Chen, Y Luo, J Yang, Q Zeng, W Luo, X Shu… - Metabolism, 2023 - Elsevier
Background Renin-independent aldosteronism (RIA) describes the spectrum of autonomous
aldosterone secretion from mild to overt. We aimed to explore whether RIA is causally …

Renin-independent aldosteronism and metabolic dysfunction-associated steatotic liver disease and cirrhosis: a genetic association study

Q Zeng, X Luo, X Chen, W Luo, R Li, S Yang, J Yang… - Clinical Nutrition, 2024 - Elsevier
Abstract Background & Aims Renin-independent aldosteronism (RIA) refers to a spectrum of
autonomous aldosterone hypersecretion. We aimed to explore the genetical relationship …