The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …

The brain is complex and dynamic. The spatial scales of interest to the neurobiologist range
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …

Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

High-resolution optical imaging deep in tissues is challenging because of optical
aberrations and scattering of light caused by the complex structure of living matter. Here we …

What is the nature of the vascular architecture in the cortex that allows the brain to meet the
energy demands of neuronal computations? We used high-throughput histology to …

Microglia are integral functional elements of the central nervous system, but the contribution
of these cells to the structural integrity of the neurovascular unit has not hitherto been …

Microinfarctions are present in the aged and injured human brain. Their clinical relevance is
controversial, with postulated sequelae ranging from cognitive sparing to vascular dementia …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

Two‐photon excitation microscopy is an alternative to confocal microscopy that provides
advantages for three‐dimensional and deep tissue imaging. This unit will describe the basic …

Optical brain imaging has seen 30 years of intense development, and has grown into a rich
and diverse field. In-vivo imaging using light provides unprecedented sensitivity to functional …