Modulating disease-relevant protein-protein interactions (PPIs) using small-molecule
inhibitors is a quite indispensable diagnostic and therapeutic strategy in averting …

Cell-penetrating peptides (CPPs) have been shown to be a transport vehicle for delivering
cargoes into live cells, offering great potential as future therapeutics. It is essential to identify …

N6-methyladenosine (m 6 A) modification is the most abundant RNA methylation
modification and involves various biological processes, such as RNA splicing and …

To gain insight into the malfunction of the Golgi apparatus and its relationship to various
genetic and neurodegenerative diseases, the identification of sub-Golgi proteins, both cis …

Gram-negative bacteria use various secretion systems to deliver their secreted effectors.
Among them, type IV secretion system exists widely in a variety of bacterial species, and …

The spatial distribution of soil organic matter (SOM) is highly significant to the assessment of
the regional carbon balance, food security and cultivated land quality. Due to climate …

Identification of hot spots, a small portion of protein-protein interface residues that contribute
the majority of the binding free energy, can provide crucial information for understanding the …

Amyloid is an insoluble fibrous protein and its mis-aggregation can lead to some diseases,
such as Alzheimer's disease and Creutzfeldt–Jakob's disease. Therefore, the identification …

Hot spots are the subset of interface residues that account for most of the binding free
energy, and they play essential roles in the stability of protein binding. Effectively identifying …

With the development of urbanization, road congestion has become increasingly serious,
and an important cause is the traffic accidents. In this article, we aim to predict the duration of …