New approaches to the dynamic interpretation and prediction of NMR relaxation data from proteins
R Brüschweiler - Current opinion in structural biology, 2003 - Elsevier
NMR relaxation experiments of isotopically labeled proteins provide a wealth of information
on reorientational global and local dynamics on nanosecond and subnanosecond …
on reorientational global and local dynamics on nanosecond and subnanosecond …
[HTML][HTML] Microsecond freeze-hyperquenching: development of a new ultrafast micro-mixing and sampling technology and application to enzyme catalysis
AV Cherepanov, S De Vries - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
A novel freeze-quench instrument with a characteristic «dead-time» of 137±18 μs is
reported. The prototype has several key features that distinguish it from conventional freeze …
reported. The prototype has several key features that distinguish it from conventional freeze …
The NMR solution structure of a mutant of the Max b/HLH/LZ free of DNA: insights into the specific and reversible DNA binding mechanism of dimeric transcription …
Basic region-helix1-loop-helix2-leucine zipper (b/H1LH2/LZ) transcription factors bind
specific DNA sequence in their target gene promoters as dimers. Max, ab/H1LH2/LZ …
specific DNA sequence in their target gene promoters as dimers. Max, ab/H1LH2/LZ …
[HTML][HTML] Identification of potential short linear motifs (SLiMs) in intrinsically disordered sequences of proteins by fast time-scale backbone dynamics
Intrinsically disordered regions (IDRs) of proteins contain functionally important short linear
motifs (SLiMs), which are composed of 3 to 10 residues. They are often crucial members in …
motifs (SLiMs), which are composed of 3 to 10 residues. They are often crucial members in …
The mechanism of discrimination between cognate and non-specific DNA by dimeric b/HLH/LZ transcription factors
The Myc/Max/Mad proteins are basic region-helix-loop-helix-leucine zipper (b/HLH/LZ)
transcription factors that regulate the transcription of numerous genes involved in cell growth …
transcription factors that regulate the transcription of numerous genes involved in cell growth …
Thermodynamic interpretation of protein dynamics from NMR relaxation measurements
L Spyracopoulos - Protein and Peptide Letters, 2005 - ingentaconnect.com
Protein dynamics and thermodynamics can be characterized through measurements of
relaxation rates of side chain 2H and 13C, and backbone 15N nuclei using NMR …
relaxation rates of side chain 2H and 13C, and backbone 15N nuclei using NMR …
Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site
PD Adams, AP Loh, RE Oswald - Biochemistry, 2004 - ACS Publications
Cdc42Hs, a member of the Ras superfamily of GTP-binding signal transduction proteins,
binds guanine nucleotides, and acts as a molecular-timing switch in multiple signal …
binds guanine nucleotides, and acts as a molecular-timing switch in multiple signal …
Structural basis of tonic inhibition by dimers of dimers in hyperpolarization-activated cyclic-nucleotide-modulated (HCN) ion channels
B VanSchouwen, G Melacini - The Journal of Physical Chemistry …, 2016 - ACS Publications
The hyperpolarization-activated cyclic-nucleotide-modulated (HCN) ion channels control
rhythmicity in neurons and cardiomyocytes. Cyclic AMP (cAMP) modulates HCN activity …
rhythmicity in neurons and cardiomyocytes. Cyclic AMP (cAMP) modulates HCN activity …
Folding kinetics and thermodynamics of Pseudomonas syringae effector protein AvrPto provide insight into translocation via the type III secretion system
JE Dawson, LK Nicholson - Protein Science, 2008 - Wiley Online Library
In order to infect their hosts, many Gram‐negative bacteria translocate agents of infection,
called effector proteins, through the type III secretion system (TTSS) into the host cytoplasm …
called effector proteins, through the type III secretion system (TTSS) into the host cytoplasm …
N-lobe dynamics of myosin light chain dictates its mode of interaction with myosin V IQ1
I Amata, M Gallo, M Pennestri, M Paci… - Biochemistry, 2008 - ACS Publications
Myosin V motors regulate secretion and cell division in eukaryotes. How MyoV activity is
differentially regulated by essential and calmodulin light chain binding remains unclear. We …
differentially regulated by essential and calmodulin light chain binding remains unclear. We …