The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of
blood pressure and body fluid homeostasis and is a mainstay for the treatment of …

Heart failure (HF) and diabetes mellitus (DM) frequently coexist, with a prevalence of DM of
35–40% in patients with HF, independent of the level of impairment of the ejection fraction …

The angiotensin converting enzyme 2 (ACE2) catalyzes the degradation of Angiotensin II
(Ang II) to generate Angiotensin-(1-7), which reduces inflammation and oxidative stress …

Diabetic kidney disease (DKD) is one of the main causes of end-stage renal disease
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …

Purpose: A multitude of animal studies substantiates the beneficial effects of Ang-(1–7), a
peptide hormone in the protective axis of the renin angiotensin system, in diabetes and its …

Previously, we had shown that a vasopeptidase inhibitor drug containing ACE and
neprilysin inhibitors was an effective treatment for diabetic vascular and neural …

Diabetes is an enormous and ever-growing calamity and a global public health threat of the
21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin …

Diabetes mellitus is a prevalent disorder with multi-system manifestations, causing a
significant burden in terms of disability and deaths globally. Angio-tensin receptor-neprilysin …

Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various
bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous …

The activation of the renin‐angiotensin system (RAS) participates in the development of
metabolic syndrome (MetS) and in heart failure. PPAR‐alpha activation by fenofibrate …