Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

The fecal mycobiome in non-alcoholic fatty liver disease

M Demir, S Lang, P Hartmann, Y Duan, A Martin… - Journal of …, 2022 - Elsevier
Background & Aims Studies investigating the gut-liver axis have largely focused on bacteria,
whereas little is known about commensal fungi. We characterized fecal fungi in patients with …

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

The role of gut bacteria and fungi in alcohol-associated liver disease

L Chen, Y Zhu, X Hou, L Yang, H Chu - Frontiers in Medicine, 2022 - frontiersin.org
Cirrhosis and liver cancer caused by alcohol-associated liver disease (ALD) are serious
threats to people's health. In addition to hepatic cell apoptosis and liver inflammation caused …

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

YS Kim, B Ko, DJ Kim, J Tak, CY Han, JY Cho… - Nature …, 2022 - nature.com
Disturbed lipid metabolism precedes alcoholic liver injury. Whether and how AhR alters
degradation of lipids, particularly phospho-/sphingo-lipids during alcohol exposure, was not …

Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota

Y Li, D Zhao, M Qian, J Liu, C Pan… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Non‐alcoholic fatty liver disease (NAFLD) represents a severe
public health problem. It often coexists with hypertension in the context of metabolic …

Pectin modulates intestinal immunity in a pig model via regulating the gut microbiota-derived tryptophan metabolite-AhR-IL22 pathway

G Dang, X Wen, R Zhong, W Wu, S Tang, C Li… - Journal of Animal …, 2023 - Springer
Background Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator,
promoting intestinal development and regulating intestinal flora in the gut. However, the …

Gut microbiota regulation of AHR signaling in liver disease

B Wang, Z Zhou, L Li - Biomolecules, 2022 - mdpi.com
Liver health plays a vital role in human health and disease. Emerging evidence has shown
the importance of the aryl hydrocarbon receptor (AHR) in liver diseases such as alcoholic …

Association between iron metabolism and non-alcoholic fatty liver disease: results from the National Health and Nutrition Examination Survey (NHANES 2017–2018) …

X Zhang, R Zuo, S Xiao, L Wang - Nutrition & Metabolism, 2022 - Springer
Background Iron metabolism may be involved in the pathogenesis of the non-alcoholic fatty
liver disease (NAFLD). The relationship between iron metabolism and NAFLD has not been …