Abstract Purpose of Review Skeletal muscle and bone are connected anatomically and
physiologically, and play a crucial role in human locomotion and metabolism. Historically …

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

Osteoporosis is characterized by reduced bone mass and disruption of bone architecture,
resulting in increased risk of fragility fractures and significant long-term disability. Although …

Skeletal muscle atrophy is a hallmark of severe spinal cord injury (SCI) that is precipitated by
the neural insult and paralysis. Additionally, other factors may influence muscle loss …

Background Although muscles and bones interact with each other through various secretory
factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not …

Sclerostin, a protein encoded by the sclerostin (SOST) gene, is mostly expressed in
osteocytes. First described in the pathogenesis of three disorders, sclerosteosis, van …

Neuromuscular impairment and reduced musculoskeletal integrity are hallmarks of spinal
cord injury (SCI) that hinder locomotor recovery. These impairments are precipitated by the …

Abstract Purpose of the Review The purpose of this review is to summarize the role of the
osteocyte in muscle atrophy in cancer patients, sarcopenia, spinal cord injury, Duchenne's …

To elucidate mechanisms of bone loss after spinal cord injury (SCI), we evaluated the time-
course of cancellous and cortical bone microarchitectural deterioration via microcomputed …

Abstract Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory
disorder characterized by progressive airflow limitation and systemic implications. It has …