While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …

Asthma is an inflammatory disorder principally involving the conducting airways and
characterised by infiltration of the airway wall with a range of inflammatory cells driven in …

For decades, enterocyte brush border microvilli have been viewed as passive cytoskeletal
scaffolds that serve to increase apical membrane surface area. However, recent studies …

Inflammation of human bronchial epithelia (HBE) activates the endoplasmic reticulum (ER)
stress transducer inositol-requiring enzyme 1 (IRE1) α, resulting in IRE1α-mediated cytokine …

Interleukin (IL)-4 and IL-13 share many biological activities. To some extent, this is because
they both signal via a shared receptor, IL-4Rα. Ligation of IL-4Rα results in activation of …

Asthma is a common respiratory disease affecting∼ 300 million people worldwide. Airway
inflammation is thought to contribute to asthma pathogenesis, but the direct relationship …

Purpose.: To investigate the effects of IL-13 on goblet cell proliferation, differentiation, and
expression of mucin and immunomodulatory genes. Methods.: Explants were excised from …

Rationale: The goal was to connect elements of idiopathic pulmonary fibrosis (IPF)
pathogenesis, including chronic endoplasmic reticulum stress in respiratory epithelia …

CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and
plays an essential role in goblet cell mucus production from the respiratory tract epithelium …