[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

Combination therapies for biofilm inhibition and eradication: a comparative review of laboratory and preclinical studies

S Hawas, AD Verderosa, M Totsika - Frontiers in cellular and infection …, 2022 - frontiersin.org
Microbial biofilms are becoming increasingly difficult to treat in the medical setting due to
their intrinsic resistance to antibiotics. To combat this, several biofilm dispersal agents are …

[HTML][HTML] Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and …

J Hu, Y Ding, B Tao, Z Yuan, Y Yang, K Xu, X Li, K Cai - Bioactive Materials, 2022 - Elsevier
Insufficient osseointegration and biofilm-associated bacterial infection are important
challenges for clinical application of titanium (Ti)-based implants. Here, we constructed …

Drug delivery strategies for antibiofilm therapy

V Choi, JL Rohn, P Stoodley, D Carugo… - Nature Reviews …, 2023 - nature.com
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …

Recent development of nanomedicine for the treatment of bacterial biofilm infections

W Xiu, J Shan, K Yang, H Xiao, L Yuwen, L Wang - View, 2021 - Wiley Online Library
Bacterial biofilm related infections are ever growing issues for global medical community.
Traditional antibiotic therapy is usually ineffective for treating them because the bacteria …

Emerging antibacterial nanomedicine for enhanced antibiotic therapy

S Wang, Y Gao, Q Jin, J Ji - Biomaterials Science, 2020 - pubs.rsc.org
Antibiotic therapy is the most powerful strategy for treating bacterial infections in clinic.
However, antibiotic resistance has become one of the biggest threats to public health …

Recent applications and strategies in nanotechnology for lung diseases

W Zhong, X Zhang, Y Zeng, D Lin, J Wu - Nano Research, 2021 - Springer
Lung diseases, including COVID-19 and lung cancers, is a huge threat to human health.
However, for the treatment and diagnosis of various lung diseases, such as pneumonia …

Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis‐Related Pseudomonas aeruginosa Biofilms

CR Thorn, CS Carvalho‐Wodarz, JC Horstmann… - Small, 2021 - Wiley Online Library
Pseudomonas aeruginosa biofilms cause persistent and chronic infections, most known
clinically in cystic fibrosis (CF). Tobramycin (TOB) is a standard anti‐pseudomonal antibiotic; …

Nanotechnologies for control of pathogenic microbial biofilms

EO Asare, EA Mun, E Marsili, VN Paunov - Journal of Materials …, 2022 - pubs.rsc.org
Biofilms are formed at interfaces by microorganisms, which congregate in microstructured
communities embedded in a self-produced extracellular polymeric substance (EPS). Biofilm …

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle

MM Hamed, AS Abdelsamie, K Rox, C Schütz… - Advanced …, 2023 - Wiley Online Library
Pseudomonas aeruginosa (PA) is an opportunistic human pathogen, which is involved in a
wide range of dangerous infections. It develops alarming resistances toward antibiotic …