Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …

Endpoint development trials are underway across the spectrum of retinal disease. New
validated endpoints are urgently required for the assessment of emerging gene therapies …

Background Choroideremia is an X-linked recessive disease that leads to blindness due to
mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed …

This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-
RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis …

BACKGROUND In retinitis pigmentosa (RP), rod photoreceptors degenerate from 1 of many
mutations, after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) …

Importance Choroideremia (CHM) is a rare, degenerative, genetic retinal disorder resulting
from mutation of theCHMgene, leading to an absence of functional ras-associated binding …

Purpose.: To determine the intrasession test–retest variability of microperimetry in
participants with age-related macular degeneration (AMD). Methods.: This study consisted of …

Background. Vision Restoration Therapy (VRT) aims to improve visual field function by
systematically training regions of residual vision associated with the activity of suboptimal …

Purpose.: To measure macular visual function in patients with unstable fixation, to define the
photoreceptor source of this function, and to estimate its test-retest repeatability as a …

Importance As currently used, microperimetry is a burdensome clinical testing modality for
testing retinal sensitivity requiring long testing times and trained technicians. Objective To …