Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Intercellular tight junctions (TJs) exhibit a complex molecular architecture involving the
regulated cointeraction of cytoplasmic adaptor proteins (eg, zonula occludens) and integral …

Background The endoplasmic reticulum (ER) is responsible for the control of correct protein
folding and protein function which is crucial for cell survival. However, under pathological …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular
mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events …

Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore
that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced …

Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients
with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is …

With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

Growing evidence of epidemiological, clinical and experimental studies has clearly shown a
close link between adverse in utero environment and the increased risk of neurological …