Abstract Adaptor-Associated Kinase 1 (AAK1), a Ser/Thr protein kinase, responsible for
regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS) …

A palladium‐catalyzed reductive difluorocarbene transfer reaction that tames
difluorocarbene to couple with two electrophiles has been developed, representing a new …

Abstract Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr
kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the …

Asymmetric phase-transfer alkylation of the N-(arylmethylene)-α-alkylamino acid ethyl esters
and N-(arylmethylene) glycine ethyl esters was found to be catalyzed by the (R)-or (S) …

Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as
a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have …

BACKGROUND: Small extracellular vesicles (sEVs) derived from M2 microglia (M2-
microglia–derived small extracellular vesicles [M2-sEVs]) contribute to central nervous …

Citron kinase (CITK) is an AGC-family serine/threonine kinase that regulates cytokinesis.
Despite knockdown experiments implicating CITK as an anticancer target, no selective CITK …

While it is true that pharmacotherapy has achieved desired health outcomes, significant
unmet medical needs persist in the field of central nervous system (CNS) drugs, particularly …

Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for
the treatment of inflammatory pain without psychiatric side effects mediated by the …

A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase
(CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets …