Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Bile acids are important physiological agents for intestinal nutrient absorption and biliary
secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling …

Intrahepatic cholestasis of pregnancy (ICP) is a poorly understood disease of the late
second or third trimester of pregnancy, typically associated with rapid resolution following …

Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease
that typically presents in the third trimester. The clinical features are maternal pruritus in the …

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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease,
characterized by maternal pruritus and raised serum bile acids. Our objectives were to …

The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …