Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

Based on fundamental chemistry, biotechnology and materials science have developed
over the past three decades into today's powerful disciplines which allow the engineering of …

Gout is a common crystal-induced arthritis, in which monosodium urate (MSU) crystals
precipitate within joints and soft tissues and elicit an inflammatory response. The causes of …

Gout is an ancient disease that still plagues us. Its pathogenic culprit, uric acid crystal
deposition in tissues, is a strong inflammatory stimulant. In recent years, the mechanisms …

Background Gout is a chronic disease of monosodium urate (MSU) crystal deposition.
Although hyperuricaemia is the central risk factor for development of gout, not all people with …

Interactions of macromolecules with growing crystalline surfaces play an important role in
biomineralization, determine survival of some organisms at low temperatures, and offer a …

Protein crystallization has been known since 1840 and can prove to be straightforward but,
in most cases, it constitutes a real bottleneck. This stimulated the birth of the …

Uric acid crystals [monosodium urate (MSU)] have emerged as an important factor for both
gouty arthritis and immune regulation. This simple crystalline structure appears to activate …

Auf der Basis der klassischen Chemie haben sich die Materialwissenschaften und die
Biotechnologie im Laufe der letzten drei Jahrzehnte zu leistungsfähigen Disziplinen …

Crystallization of monosodium urate monohydrate (MSU) leads to painful gouty arthritis.
Despite extensive research it is still unknown how this pathological biomineralization occurs …