Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

The conversion of mechanical energy into biochemical changes within living cells is process
known as mechanotransduction. Bone is a quintessential tissue for studying the molecular …

The WNT pathway has become an attractive target for skeletal therapies. High-bone-mass
phenotypes in patients with loss-of-function mutations in the LRP5/6 inhibitor Sost …

Physical mechanical stimulation can maintain and even increase bone mass. Here, we
report an important role of osteocytic integrin α5 in regulating the anabolic response of bone …

Much is known about skeletal adaptation in relation to the mechanical functions that bones
serve. This includes how bone adapts to mechanical loading during an individual's lifetime …

In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …

Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and
microarchitectural deterioration of bone tissue. The World Health Organization has defined …

Skeletal development and remodeling of adult bone are critically controlled by activated
NOTCH signaling in genetically modified mice. It is yet unclear whether NOTCH signaling is …

Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble
inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it …