Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to
infection. This inappropriate response to micro-organism invasion is characterized by an …

Patients who survive sepsis can develop long-term immune dysfunction, with expansion of
the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. 1 These dysregulated host responses underpin the clinical …

In April 2013, a symposium was organized to highlight different aspects of differentiation and
activation of the monocyte‐macrophage lineage as analyzed on the flow cytometer …

Inflammasome signalling induces the processing and secretion of interleukin (IL)-1β and IL-
18 which, coupled with pyroptosis, activate further the inflammatory response. In the present …

Macrophage plasticity is an important feature of these innate immune cells. Macrophage
phenotypes are divided into two categories, the classically activated macrophages (CAM …

Circulating lymphocyte number was significantly decreased in patients with sepsis.
However, it remains unknown which severity phase (sepsis, severe sepsis, and septic …

Macrophage polarization is a concept that has been useful to describe the different features
of macrophage activation related to specific functions. Macrophage polarization is …