Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

Effective therapy for Alzheimer's disease is a major challenge in the pharmaceutical
sciences. There are six FDA approved drugs (eg, donepezil, memantine) that show some …

Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

Subtyping patients into subgroups based on biotypes has emerged as a useful approach for
studying heterogeneous diseases. Understanding biotypes of HIV-associated …

Environmental factors such as chemicals, stress and pathogens are now widely believed to
play important roles in the onset of some brain diseases, as they are associated with …

This paper reports the proceedings of a virtual meeting convened by the European
Interdisciplinary Council on Ageing (EICA), to discuss the involvement of infectious disorders …

Background Neurocognitive impairment (NCI) in people with HIV (PWH) on antiretroviral
therapy (ART) is common and may result from persistent HIV replication in the central …

Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat)
protein, which has several functions that promote viral replication, pathogenesis, and …

People over the age of 50 are the fastest growing segment of the HIV-infected population in
the USA. Although antiretroviral therapy has remarkable success controlling the systemic …