Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and
available therapies, including immunotherapies, are ineffective for many patients. HCC is …

T cell function and fate can be influenced by several metabolites: in some cases, acting
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …

The hypoxic tumor microenvironment has been implicated in immune escape, but the
underlying mechanism remains elusive. Using an in vitro culture system modeling human T …

In order to fuel their relentless expansion, cancers must expand their vasculature to augment
delivery of oxygen and essential nutrients. The disordered web of irregular vessels that …

T cells engineered to express chimeric antigen receptors (CARs) have shown remarkable
success in treating B-cell malignancies, reflected by multiple US Food and Drug …

CD8+ T cells are the front-line defensive cells against cancer. Reduced infiltration and
effector function of CD8+ T cells occurs in cancer and is contributed to defective immunity …

The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response
to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But the …

Significance: Limited oxygen availability (hypoxia) commonly occurs in a range of
physiological and pathophysiological conditions, including embryonic development …