ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated
anabolic program in response to growth-promoting signals. Paradoxically, recent studies …

The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via
the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often …

The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell
differentiation and animal development remains largely unclear. Using two conditional …

Millions of COVID-19 patients have succumbed to respiratory and systemic inflammation.
Hyperstimulation of toll-like receptor (TLR) signaling is a key driver of immunopathology …

How transcription factor dimerization impacts DNA-binding specificity is poorly understood.
Guided by protein dimerization properties, we examined DNA binding specificities of 270 …

Abstract Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory
protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all …

Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The
stroma may play a critical role in this process by providing nutrients to support the epithelial …

Cancer cells exploit many of the cellular adaptive responses to support their survival needs.
One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is …