Environmental influences on the epigenome: exposure-associated DNA methylation in human populations
EM Martin, RC Fry - Annual review of public health, 2018 - annualreviews.org
DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …
environmental exposures. To date, numerous studies have detailed the manner by which …
Function of PM2. 5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases
R Li, R Zhou, J Zhang - Oncology letters, 2018 - spandidos-publications.com
Previous research has identified that air pollution is associated with various respiratory
diseases, but few studies have investigated the function served by particulate matter 2.5 …
diseases, but few studies have investigated the function served by particulate matter 2.5 …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …
environmental health researchers studying the environmental influences on human …
The environment, epigenome, and asthma
Asthma prevalence has been on the increase, especially in North America compared with
other continents. However, the prevalence of asthma differs worldwide, and in many …
other continents. However, the prevalence of asthma differs worldwide, and in many …
Use of an exposome approach to understand the effects of exposures from the natural, built, and social environments on cardio-vascular disease onset, progression …
Obesity, diabetes, and hypertension have increased by epidemic proportions in recent years
among African Americans in comparison to Whites resulting in significant adverse …
among African Americans in comparison to Whites resulting in significant adverse …
Particulate air pollution and fasting blood glucose in nondiabetic individuals: associations and epigenetic mediation in the normative aging study, 2000–2011
Background: Among nondiabetic individuals, higher fasting blood glucose (FBG)
independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2 …
independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2 …
The Impact of External Factors on the Epigenome: In Utero and over Lifetime
EG Toraño, MG García… - BioMed research …, 2016 - Wiley Online Library
Epigenetic marks change during fetal development, adult life, and aging. Some changes
play an important role in the establishment and regulation of gene programs, but others …
play an important role in the establishment and regulation of gene programs, but others …
Long-term air pollution exposure, genome-wide DNA methylation and lung function in the LifeLines cohort study
AJ de FC Lichtenfels, DA Van Der Plaat… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Long-term air pollution exposure is negatively associated with lung function,
yet the mechanisms underlying this association are not fully clear. Differential DNA …
yet the mechanisms underlying this association are not fully clear. Differential DNA …
How the genome got a life span
M Lappé, H Landecker - New genetics and society, 2015 - Taylor & Francis
In the space of little more than a decade, ideas of the human genome have shifted
significantly, with the emergence of the notion that the genome of an individual changes with …
significantly, with the emergence of the notion that the genome of an individual changes with …
Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in …
Background Changes in DNA methylation have been associated with traffic-related air
pollution in observational studies, but the specific mechanisms and temporal dynamics …
pollution in observational studies, but the specific mechanisms and temporal dynamics …