The multifunctional human ocular melanocortin system
CLS Wu, AV Cioanca, MC Gelmi, L Wen… - Progress in Retinal and …, 2023 - Elsevier
Immune privilege in the eye involves physical barriers, immune regulation and secreted
proteins that together limit the damaging effects of intraocular immune responses and …
proteins that together limit the damaging effects of intraocular immune responses and …
[HTML][HTML] Biological Immune Mechanism of Retina
X Zhu, J Hong, X Zhou - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
The blood-retinal barrier (BRB) is a well-recognized mechanism that underlies the retina's
immunological privilege. The BRB is formed locally by inhibitory molecules that bind to cell …
immunological privilege. The BRB is formed locally by inhibitory molecules that bind to cell …
[HTML][HTML] Stimulating the melanocortin system in uveitis and diabetes preserves the structure and anti-inflammatory activity of the retina
TF Ng, AW Taylor - International Journal of Molecular Sciences, 2023 - mdpi.com
The endogenous neuropeptide α-Melanocyte Stimulating Hormone (α-MSH) is a potent
suppressor of inflammation and has an essential role in maintaining the normal anti …
suppressor of inflammation and has an essential role in maintaining the normal anti …
[HTML][HTML] Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats
Retinal vascular diseases and consequential metabolic disturbances in the eye are major
concerns for healthcare systems all around the world. BGP-15, a drug candidate small …
concerns for healthcare systems all around the world. BGP-15, a drug candidate small …
[HTML][HTML] Melanocortins and Their Potential for the Treatment, Prevention and Amelioration of Complications of Diabetes
GN Robinson, RJ Pickering - Diabetology, 2024 - mdpi.com
Diabetes mellitus (type I and II) is an advancing global health problem, concerningly
increasing in prevalence in most of the developed and developing world. Current therapies …
increasing in prevalence in most of the developed and developing world. Current therapies …
[HTML][HTML] Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion
TF Ng, JY Cho, JL Zhao, JR Gardiner, ES Wang… - Biomolecules, 2024 - mdpi.com
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes
protects the retinas from degeneration. The retinal cells are protected from oxidative and …
protects the retinas from degeneration. The retinal cells are protected from oxidative and …