Fungal-mediated disease progression and antifungal drug efficacy are significantly
impacted by the dynamic infection microenvironment. At the site of infection, oxygen often …

The dimorphic fungi of the Paracoccidioides genus are the causative agents of
paracoccidioidomycosis (PCM). This disease is endemic in Latin America and primarily …

The genus Paracoccidioides comprises the species complex causing
paracoccidioidomycoses (PCM). These fungi are a serious public health problem due to the …

Nitrogen is a crucial nutrient for microorganisms that compose essential biomolecules.
However, hosts limit this nutrient as a strategy to counter infections, therefore, pathogens …

Heme is an active center in many proteins. Here we explore computationally the role of
heme in protein folding and protein structure. We model heme proteins using a hybrid model …

Paracoccidioides spp. are thermally dimorphic fungi that cause paracoccidioidomycosis and
can affect both immunocompetent and immunocompromised individuals. The infection can …

Aerobic organisms require oxygen for energy. In the course of the infection, adaptation to
hypoxia is crucial for survival of human pathogenic fungi. Members of the Paracoccidioides …

Fungi of the Paracoccidioides genus are the etiological agents of the systemic mycosis
paracoccidioidomycosis and, when in the host, they find a challenging environment that is …

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America.
Since the first description of the disease by Lutz up to the present day, Brazilian researchers …

Fungi of the Paracoccidioides genus are the etiological agents of the systemic mycosis
paracoccidioidomycosis and, when in the host, they find a challenging environment that is …