Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material
science and synthetic chemistry. Many excellent reviews have discussed acid/base …

Site-selective deuteration of C–H bonds increases the lifetime and efficacy of drug
molecules. Although effective methods to form C (sp 2)–D bonds are known, processes for …

We report a method for the electrochemical deuteration of α, β‐unsaturated carbonyl
compounds under catalyst‐and external‐reductant‐free conditions, with deuteration rates as …

Deuterium‐labeled compounds are of importance in chemical, environmental, and
biological fields. Preparation methods for deuterium‐labeled compounds have been studied …

Fundamental to the synthesis of enantioenriched chiral molecules is the ability to assign
absolute configuration at each stereogenic center, and to determine the enantiomeric …

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free
Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 …

This short review describes the recent emergence of organosodium chemistry, motivated by
the requirements of modern synthetic chemistry for sustainability, and powered by the use of …

In organic chemistry, the use of deuterium exchange as a tool to study the mechanism of
chemical reaction has been well explored. Since two decades, the research focus on …

Recent work in drug discovery has shown that selectively deuterated small molecules can
improve the safety and efficacy for active pharmaceutical ingredients. The advantages …