Endosomal sorting and signalling: an emerging role for sorting nexins
PJ Cullen - Nature reviews Molecular cell biology, 2008 - nature.com
The endocytic network comprises a series of interconnected tubulo-vesicular membranous
compartments that together regulate various sorting and signalling events. Although it is …
compartments that together regulate various sorting and signalling events. Although it is …
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy
E Zavodszky, MNJ Seaman, K Moreau… - Nature …, 2014 - nature.com
Endosomal protein sorting controls the localization of many physiologically important
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …
[HTML][HTML] Structural mechanism for cargo recognition by the retromer complex
M Lucas, DC Gershlick, A Vidaurrazaga, AL Rojas… - Cell, 2016 - cell.com
Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
E Miura, T Hasegawa, M Konno, M Suzuki… - Neurobiology of …, 2014 - Elsevier
Mutations in vacuolar protein sorting 35 (VPS35) have been linked to familial Parkinson's
disease (PD). VPS35, a component of the retromer, mediates the retrograde transport of …
disease (PD). VPS35, a component of the retromer, mediates the retrograde transport of …
The retromer complex: from genesis to revelations
MNJ Seaman - Trends in biochemical sciences, 2021 - cell.com
The retromer complex has a well-established role in endosomal protein sorting, being
necessary for maintaining the dynamic localisation of hundreds of membrane proteins that …
necessary for maintaining the dynamic localisation of hundreds of membrane proteins that …
Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila
T Inoshita, T Arano, Y Hosaka, H Meng… - Human molecular …, 2017 - academic.oup.com
Mutations of the retromer component Vps35 and endosomal kinase LRRK2 are linked to
autosomal dominant forms of familial Parkinson's disease (PD). However, the physiological …
autosomal dominant forms of familial Parkinson's disease (PD). However, the physiological …
Rab GTPase regulation of retromer-mediated cargo export during endosome maturation
TT Liu, TS Gomez, BK Sackey… - Molecular biology of …, 2012 - Am Soc Cell Biol
The retromer complex, composed of sorting nexin subunits and a Vps26/Vps29/Vps35
trimer, mediates sorting of retrograde cargo from the endosome to the trans-Golgi network …
trimer, mediates sorting of retrograde cargo from the endosome to the trans-Golgi network …
RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation
CL Freeman, G Hesketh… - Journal of cell …, 2014 - journals.biologists.com
Retromer is a vital element of the endosomal protein sorting machinery and comprises two
subcomplexes that operate together to sort membrane proteins (cargo) and tubulate …
subcomplexes that operate together to sort membrane proteins (cargo) and tubulate …
Receptor recycling by retromer
The highly conserved retromer complex controls the fate of hundreds of receptors that pass
through the endolysosomal system and is a central regulatory node for diverse metabolic …
through the endolysosomal system and is a central regulatory node for diverse metabolic …