Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short
of revealing the complete genomic landscape of a tumour. With an expanding repertoire of …

Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real
time liquid biopsy. They are however present in a large background of hematopoietic cells …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

Simple Summary Cutaneous melanoma represents the most aggressive form of skin cancer
and its occurrence, development, and progression are based on the accumulation of several …

In the last several years, nanoscale vesicles that originate from tumor cells and which can be
found circulating in the blood (ie exosomes and microvesicles) have been discovered to …

This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

Cancer remains the leading cause of death worldwide despite the enormous efforts that are
made in the development of cancer biology and anticancer therapeutic treatment …

Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw.
They represent not only the primary tumor site, but also potential metastatic lesions, and …

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have been recently
investigated in several cancer types, but their respective clinical significance remains to be …

Diagnosing and screening for tumors through noninvasive means represent an important
paradigm shift in precision medicine. In contrast to tissue biopsy, detection of circulating …