The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …

Tolerance to self-antigens prevents the elimination of cancer by the immune system,. We
used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and …

In situ cancer vaccination refers to any approach that exploits tumour antigens available at a
tumour site to induce tumour-specific adaptive immune responses. These approaches hold …

In the past decades, our knowledge about the relationship between cancer and the immune
system has increased considerably. Recent years' success of cancer immunotherapy …

Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …

Tumor microenvironment is the general term for all non-cancer components and their
metabolites in tumor tissue. These components include the extracellular matrix, fibroblasts …

Macrophages are essential components of the inflammatory microenvironment of tumors.
Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs …

As a DNA receptor, cyclic GMP-AMP synthase (cGAS) plays a crucial role in the immune
system by recognizing abnormal DNA in the cytoplasm and activating the stimulator of …

The rising interest for precise characterization of the tumour immune contexture has recently
brought forward the high potential of RNA sequencing (RNA-seq) in identifying molecular …