Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has
been linked to an elevated risk for many chronic diseases. The discovery of myokines …

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple
tissues that when repeated regularly (ie, training) improves physiological capacity, benefits …

Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by
which PA prevents disease and improves health outcomes are poorly understood. To …

The molecular transducers of benefits from different exercise modalities remain incompletely
defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance …